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Because of the extremely long terminal elimination half-life of mefloquine it is practically impossible to measure quantitatively its urinary excretion after a single dose. Indeed, a correct estimation would require collection of urine over a period of several months. This difficulty was overcome by measuring excretion in the course of a multiple-dose study when steady-state conditions had been reached. Six male African volunteers were given at an interval of 1 week 250 mg mefloquine base in the form of its hydrochloride. Urine was quantitatively collected from each subject during the 11th week and analyzed for unchanged drug and its alcohol and acid metabolites. Excretion of the unchanged drug and of its acid metabolite amounted respectively to 9% (5.2-13.1%) and 4.2% (2.9-6.2%) of the weekly dose. Concentrations of the alcohol metabolite were too low to be measured.
D E Schwartz, and
G Eckert, and
J M Ekue
February 1982,
Research communications in chemical pathology and pharmacology,
D E Schwartz, and
G Eckert, and
J M Ekue
May 1971,
Research communications in chemical pathology and pharmacology,
D E Schwartz, and
G Eckert, and
J M Ekue
February 1996,
Therapeutic drug monitoring,
D E Schwartz, and
G Eckert, and
J M Ekue
June 1989,
Xenobiotica; the fate of foreign compounds in biological systems,
D E Schwartz, and
G Eckert, and
J M Ekue
January 2018,
PLoS neglected tropical diseases,
D E Schwartz, and
G Eckert, and
J M Ekue
January 1986,
Masui. The Japanese journal of anesthesiology,
D E Schwartz, and
G Eckert, and
J M Ekue
June 1978,
Pharmacological research communications,
D E Schwartz, and
G Eckert, and
J M Ekue
May 2001,
Scandinavian journal of clinical and laboratory investigation,
D E Schwartz, and
G Eckert, and
J M Ekue
August 1981,
Journal of pharmaceutical sciences,
D E Schwartz, and
G Eckert, and
J M Ekue
January 1993,
Acta haematologica,
