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In order to investigate the mechanism of expression of the human alpha 1-antitrypsin (alpha 1-AT) gene in macrophages, we have characterized the alpha 1-AT transcriptional units in these cells and discovered that there is a macrophage-specific promoter located approximately 2000 bp upstream of the hepatocyte-specific promoter. Transcription from the two alpha 1-AT promoters is mutually exclusive: the macrophage promoter is silent in hepatocytes and the hepatocyte promoter is silent in macrophages. In addition, in macrophages two distinct mRNAs are generated transcript by alternative splicing. These results suggest that alpha 1-AT gene transcription responds to two different cell-specific regulatory mechanisms.
E Perlino, and
R Cortese, and
G Ciliberto
July 1999,
Biochimica et biophysica acta,
E Perlino, and
R Cortese, and
G Ciliberto
November 2020,
Biochemical and biophysical research communications,
E Perlino, and
R Cortese, and
G Ciliberto
June 1996,
Bioscience reports,
E Perlino, and
R Cortese, and
G Ciliberto
November 1979,
Lancet (London, England),
E Perlino, and
R Cortese, and
G Ciliberto
September 1981,
Journal of clinical pathology,
E Perlino, and
R Cortese, and
G Ciliberto
March 1996,
Human gene therapy,
E Perlino, and
R Cortese, and
G Ciliberto
June 1996,
European journal of biochemistry,
E Perlino, and
R Cortese, and
G Ciliberto
February 2006,
Gene,
E Perlino, and
R Cortese, and
G Ciliberto
June 1991,
Blood,
E Perlino, and
R Cortese, and
G Ciliberto
September 1987,
Nucleic acids research,
