-transparent.png){kind=logo}
In this article a simple method for the determination of 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in biological fluids is presented, based on reversed-phase ion-pair HPLC with UV detection at 254 nm. No complicated extraction procedure is needed. The stationary phase consists of a reversed-phase C18 stainless steel column and the mobile phase of 0.005 M sodium acetate and 0.0025 M pentanesulfonic acid sodium salt (PIC-B5) as an ion-pair reagent in water (pH 6.5). DHPG is a new antiviral drug in research of the treatment of cytomegalovirus infections. As a pilot study serum and urine samples of a few patients were investigated to gain an impression of the therapeutic range of DHPG. The method is suitable for routine assay of DHPG.
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
September 1987,
Annals of internal medicine,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
March 1987,
Journal of chromatography,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
January 1987,
Current eye research,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
August 1986,
Annals of internal medicine,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
January 1989,
Yao xue xue bao = Acta pharmaceutica Sinica,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
February 1988,
Transplantation proceedings,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
April 1986,
Annals of internal medicine,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
July 1984,
Journal of pharmaceutical sciences,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
May 1983,
Antimicrobial agents and chemotherapy,
E H Wiltink, and
P Stekkinger, and
J A Brakenhoff, and
S A Danner
August 1989,
Ugeskrift for laeger,
