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The anti-herpes simplex virus (HSV) effect and cytotoxicity of a new nucleoside analogue, 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) in rabbit cornea were studied. In tests of the anti-HSV effect of DHPG, even 0.03% ointment, given 5 times per day for 2 days, prevented lesion formation. The preventive effect of DHPG was much stronger than that of acyclovir (ACV) or 5-iodo-2'-deoxyuridine (IDU). In tests on the therapeutic effect of DHPG against dendritic ulcers, 0.3% ointment, given 5 times per day for 4 days, had a dramatic therapeutic effect. The effect was stronger than that of 3% ACV or 0.5% IDU ointment. Application of 0.3%, 1% or 3% DHPG ointment to normal rabbit corneas, 5 times per day for 2 weeks resulted in no histopathological abnormalities. The above results show that DHPG is superior to ACV or IDU for treatment of HSV infections.
H Shiota, and
T Naito, and
Y Mimura
January 1989,
Yao xue xue bao = Acta pharmaceutica Sinica,
H Shiota, and
T Naito, and
Y Mimura
October 1983,
The Journal of biological chemistry,
H Shiota, and
T Naito, and
Y Mimura
February 1984,
The Journal of biological chemistry,
H Shiota, and
T Naito, and
Y Mimura
September 1987,
Annals of internal medicine,
H Shiota, and
T Naito, and
Y Mimura
February 1987,
Antimicrobial agents and chemotherapy,
H Shiota, and
T Naito, and
Y Mimura
May 1983,
Antimicrobial agents and chemotherapy,
H Shiota, and
T Naito, and
Y Mimura
September 1984,
Antimicrobial agents and chemotherapy,
H Shiota, and
T Naito, and
Y Mimura
April 1985,
Biochemical pharmacology,
H Shiota, and
T Naito, and
Y Mimura
October 1987,
Pharmaceutisch weekblad. Scientific edition,
H Shiota, and
T Naito, and
Y Mimura
April 1984,
Journal of virology,
