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Surface markers expressed on histiocytosis X (HX) cells were studied using 18 monoclonal antibodies (McAbs) and an in situ indirect immunoperoxidase technique. Specimens of skin (five biopsies from three cases) and lymph node (one case) were studied. Our study confirmed previous findings of an OKT6+ HLA DR+ Leu 3a+ phenotype of HX cells in skin and indicated that lymph node HX cells can also have this phenotype. A mixture of cells expressing T markers/T subset, monocyte/macrophage, and killer/natural killer (K/NK) markers was also present in two cases. However, one case with an aggressive course showed no detectable HNK 1+ (K/NK) or Leu 2A (suppressor) cells in the cutaneous infiltrates and no detectable HNK 1+ lymphocytes in an affected lymph node. The significance of these findings in relation to prognosis and therapy is discussed.
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
March 1983,
American journal of clinical pathology,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
June 1983,
Pathology, research and practice,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
July 1992,
Histology and histopathology,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
January 1983,
Hybridoma,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
January 1990,
Current problems in dermatology,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
January 1987,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
January 1983,
Journal of immunology (Baltimore, Md. : 1950),
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
July 1986,
Blood,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
July 1988,
International journal of cancer,
E M McMillan, and
G B Humphrey, and
L Stoneking, and
L C Strauss, and
C I Civin, and
T Abo, and
C Balch
January 1990,
Leukemia research,
