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Cutaneous lesions in three cases of histiocytosis-X were studied by light microscopy, electron microscopy, and immunoperoxidase technics. In each case, Birbeck granule-containing histiocytosis-X cells infiltrated the epidermis and were apposed to lymphocytes. The histiocytosis-X cells and normal Langerhans cells stained with anti-T6 and anti-I1 (Ia-like) antibodies but were negative with anti-T3, anti-T8, anti-M1, and anti-lysozyme antibodies. In addition, the histiocytosis-X cells also stained with anti-T4 antibodies, which react with T-cells associated with helper/inducer phenotype. This study supports the hypothesis that histiocytosis-X cells are abnormal Langerhans cells. The presence of T4/T6-positive cells in cutaneous disease may be a marker for abnormal Langerhans cells.
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
February 1984,
Journal of cutaneous pathology,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
December 1984,
The British journal of dermatology,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
January 1987,
Annales de dermatologie et de venereologie,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
June 1983,
Pathology, research and practice,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
March 1986,
Clinical immunology and immunopathology,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
January 1991,
Virchows Archiv. A, Pathological anatomy and histopathology,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
January 1985,
Indian journal of leprosy,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
November 1985,
American journal of clinical pathology,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
September 1980,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
T J Harrist, and
A K Bhan, and
G F Murphy, and
S Sato, and
R S Berman, and
S E Gellis, and
S Freedman, and
M C Mihm
August 1981,
Clinical and experimental immunology,
