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Mutagenicity of several nitroso derivatives of piperazine was assayed using histidine auxotrophic strains of Salmonella typhimurium. Nitroso derivatives of piperazine required metabolic activation with preference to phenobarbital induced rat-liver microsomal enzymes. We observed a good correlation between a positive effect in the mutation assay and the carcinogenic potency of the compound. Even though our results are not in complete agreement with earlier published work using several microbial mutation assay systems, the differences we observed demonstrate the predictive value of an in vitro activation system using S. typhimurium to detect carcinogenic compounds as mutagens.
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
February 1980,
Mutation research,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
March 1978,
Mutation research,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
January 1995,
International journal of occupational medicine and environmental health,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
March 1978,
Mutation research,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
April 1992,
Chemical & pharmaceutical bulletin,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
May 1983,
European journal of cancer & clinical oncology,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
July 2002,
Chemical & pharmaceutical bulletin,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
December 1986,
Journal of pharmacobio-dynamics,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
January 1984,
Environmental mutagenesis,
T K Rao, and
J A Young, and
W Lijinsky, and
J L Epler
June 1979,
Mutation research,
