-transparent.png){kind=logo}
In 5 patients with cirrhosis and ascites the glomerular filtration rate (GFR), free water clearance (CH2O) and urinary excretion of prostaglandin E2(PGE2) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha) were measured before and after a 3-day treatment with sulindac (400 mg/day). The administration of sulindac induced a marked fall of urinary excretion of PGE2 (from 24.2 +/- 5.5 to 3.8 +/- 1.1 ng/h; p less than 0.05), 6-keto-PGF1 alpha (from 19.9 +/- 2.9 to 5.6 +/- 1.1 ng/h; p less than 0.02) GFR (from 111 +/- 15 to 67 +/- 10 ml/min; p less than 0.01) and CH2O (from 7 +/- 1.5 to 3.7 +/- 1.3 ml/min; p less than 0.02) in all patients studied. The plasma concentration of the active metabolite sulindac sulfide in cirrhotics was 400% of that found in 6 healthy volunteers (9.6 +/- 1.7 vs. 2.4 +/- 0.6 ng/ml). Our results indicate that sulindac, at a dose of 400 mg/day, inhibits the renal synthesis of prostaglandins and impairs renal function in cirrhotics with ascites. These effects are probably related to the marked alteration of sulindac kinetics that occurs in these patients.
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
October 1985,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
March 1986,
Scandinavian journal of gastroenterology,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
January 1997,
Hepato-gastroenterology,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
May 1980,
Gastroenterology,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
January 1986,
Progress in liver diseases,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
January 1986,
Gastroenterology,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
February 2002,
British journal of pharmacology,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
January 1982,
Urologiia i nefrologiia,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
December 1950,
The Journal of laboratory and clinical medicine,
E Quintero, and
P Ginés, and
V Arroyo, and
A Rimola, and
J Camps, and
J Gaya, and
A Guevara, and
M Rodamilans, and
J Rodés
October 1986,
Revista medica de Chile,
