Microstructural white matter abnormalities in multiple sclerosis and neuromyelitis optica spectrum disorders: Evaluation by advanced diffusion imaging. 2022

Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, Japan; Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Despite differences in the pathogenesis and treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD), it remains difficult to distinguish them. In this study, we aimed to discriminate between MS and NMOSD using diffusion tensor imaging (DTI), free water (FW) imaging, and neurite orientation dispersion and density imaging (NODDI). Thirty patients with relapsing-remitting (RR) MS, 18 NMOSD patients with positive anti-aquaporin-4 immunoglobulin G seroreactivity, and 20 age- and sex- matched currently healthy subjects underwent MRI. The differences in the DTI (fractional anisotropy [FA], axial diffusivity [AD], mean diffusivity [MD], and radial diffusivity [RD]), FW and FW-corrected DTI, and NODDI indices between the three groups were evaluated using tract-based spatial statistics (TBSS) and region-of-interest (ROI) analyses. The ROI analysis of lesions indicated that the RRMS group had significantly higher AD, MD, RD, ISO and FW-corrected AD, and MD; and lower intracellular volume fraction (ICVF) than the NMOSD group. TBSS analysis showed increased water content in RRMS patients compared to NMOSD patients. Compared with healthy controls (HCs) using TBSS and ROI analysis, the changes in FW imaging indices were more limited than those of in DTI in RRMS patients. FW imaging and NODDI were useful for identifying the etiology of neurodegeneration- and neuroinflammation-related microstructural changes in RRMS and NMOSD patients.

UI MeSH Term Description Entries
D009103 Multiple Sclerosis An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903) MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D009471 Neuromyelitis Optica A syndrome characterized by acute OPTIC NEURITIS; MYELITIS, TRANSVERSE; demyelinating and/or necrotizing lesions in the OPTIC NERVES and SPINAL CORD; and presence of specific autoantibodies to AQUAPORIN 4. Devic Disease,Devic's Neuromyelitis Optica,Devic Neuromyelitis Optica,Devic Syndrome,Devic's Disease,Devic's Syndrome,NMO Spectrum Disorder,Neuromyelitis Optica (NMO) Spectrum Disorder,Neuromyelitis Optica (NMO) Spectrum Disorders,Neuromyelitis Optica Spectrum Disorder,Neuromyelitis Optica Spectrum Disorders,Devic Neuromyelitis Opticas,Devics Disease,Devics Neuromyelitis Optica,Devics Syndrome,Disease, Devic,Disease, Devic's,NMO Spectrum Disorders,Neuromyelitis Optica, Devic,Neuromyelitis Optica, Devic's,Neuromyelitis Opticas, Devic,Syndrome, Devic,Syndrome, Devic's
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014867 Water A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Hydrogen Oxide
D049292 Leukoaraiosis Non-specific white matter changes in the BRAIN, often seen after age 65. Changes include loss of AXONS; MYELIN pallor, GLIOSIS, loss of ependymal cells, and enlarged perivascular spaces. Leukoaraiosis is a risk factor for DEMENTIA and CEREBROVASCULAR DISORDERS. Leukoaraioses
D056324 Diffusion Tensor Imaging The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules. Diffusion Tractography,DTI MRI,Diffusion Tensor MRI,Diffusion Tensor Magnetic Resonance Imaging,Diffusion Tensor MRIs,Imaging, Diffusion Tensor,MRI, Diffusion Tensor,Tractography, Diffusion
D020529 Multiple Sclerosis, Relapsing-Remitting The most common clinical variant of MULTIPLE SCLEROSIS, characterized by recurrent acute exacerbations of neurologic dysfunction followed by partial or complete recovery. Common clinical manifestations include loss of visual (see OPTIC NEURITIS), motor, sensory, or bladder function. Acute episodes of demyelination may occur at any site in the central nervous system, and commonly involve the optic nerves, spinal cord, brain stem, and cerebellum. (Adams et al., Principles of Neurology, 6th ed, pp903-914) Multiple Sclerosis, Acute Relapsing,Relapsing-Remitting Multiple Sclerosis,Acute Relapsing Multiple Sclerosis,Remitting-Relapsing Multiple Sclerosis,Multiple Sclerosis, Relapsing Remitting,Multiple Sclerosis, Remitting-Relapsing,Relapsing Remitting Multiple Sclerosis,Remitting Relapsing Multiple Sclerosis
D066127 White Matter The region of CENTRAL NERVOUS SYSTEM that appears lighter in color than the other type, GRAY MATTER. It mainly consists of MYELINATED NERVE FIBERS and contains few neuronal cell bodies or DENDRITES. Cerebellar White Matter,Cerebellar White Matters,Matter, Cerebellar White,Matter, White,Matters, Cerebellar White,Matters, White,White Matter, Cerebellar,White Matters,White Matters, Cerebellar

Related Publications

Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
July 2017, European journal of neurology,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
January 2024, Multiple sclerosis journal - experimental, translational and clinical,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
June 2021, Schmerz (Berlin, Germany),
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
September 2020, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
January 2021, Frontiers in neurology,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
January 2022, Current pharmaceutical design,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
December 2012, Journal of neuroradiology = Journal de neuroradiologie,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
February 2019, The Lancet. Neurology,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
January 2023, Journal of neurology, neurosurgery, and psychiatry,
Shimpei Kato, and Akifumi Hagiwara, and Kazumasa Yokoyama, and Christina Andica, and Yuji Tomizawa, and Yasunobu Hoshino, and Wataru Uchida, and Yuma Nishimura, and Shohei Fujita, and Koji Kamagata, and Masaaki Hori, and Nobutaka Hattori, and Osamu Abe, and Shigeki Aoki
February 2017, European journal of neurology,
Copied contents to your clipboard!