Biomaterial Database

Correlative relationship between proteinase production, adherence and pathogenicity of various strains of Candida albicans. 1986

M Ghannoum, and K Abu Elteen

Fifty-three isolates of Candida albicans, representing seven strain types, were tested for their proteinase production and this parameter was correlated with adherence to buccal epithelial cells in 23 isolates and lethality to mice for 14 isolates. Variation in proteinase production and adherence existed both among isolates of the same strain type and different strain types. All isolates tested, irrespective of strain type or source, excreted an inducible proteinase and showed a tendency towards epithelial adherence. A correlation was found between adherence, proteinase production and pathogenicity. The C. albicans isolates which adhered most strongly to buccal epithelial cells had the highest relative proteinase activities and were most pathogenic. This was obvious with strain type--C--, which had a higher prevalence than other strain types in both patients and control groups. These results emphasize the role played by some specific properties of certain strains of C. albicans in the pathogenesis of candidosis.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009061	Mouth Mucosa	Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.	Buccal Mucosa,Oral Mucosa,Mucosa, Mouth,Mucosa, Oral
D010450	Endopeptidases	A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.	Endopeptidase,Peptide Peptidohydrolases
D002176	Candida albicans	A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).	Candida albicans var. stellatoidea,Candida stellatoidea,Dematium albicans,Monilia albicans,Myceloblastanon albicans,Mycotorula albicans,Parasaccharomyces albicans,Procandida albicans,Procandida stellatoidea,Saccharomyces albicans,Syringospora albicans
D002610	Cheek	The part of the face that is below the eye and to the side of the nose and mouth.	Bucca,Buccas,Cheeks
D004848	Epithelium	The layers of EPITHELIAL CELLS which cover the inner and outer surfaces of the cutaneous, mucus, and serous tissues and glands of the body.	Mesothelium,Epithelial Tissue,Mesothelial Tissue,Epithelial Tissues,Mesothelial Tissues,Tissue, Epithelial,Tissue, Mesothelial,Tissues, Epithelial,Tissues, Mesothelial
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000268	Adhesiveness	A property of the surface of an object that makes it stick to another surface.	Adhesivenesses
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014774	Virulence	The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.	Pathogenicity