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Recent reports have suggested that the sensitivity to chemotherapy of endocrine-dependent breast cancer may be enhanced by transient exposure to hormonal stimulation. To test this concept, 39 postmenopausal women with proven metastatic breast carcinoma and measurable disease were entered into this prospective, double-blind trial; 35 are currently evaluable. All patients were continuously treated with aminoglutethimide and hydrocortisone to lower estrogen production, plus cyclic chemotherapy. Patients in the "stimulation" arm received in addition, Estrace 2 mg b.i.d. sublingually for 3 days before and on the day of chemotherapy. Estrace administration appeared to accelerate tumor growth as demonstrated by increased bone pain, hypercalcemia, and growth of skin lesions. Response rates, response duration, and survival were similar in the stimulation and control groups.
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
January 1988,
Oncology,
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
July 1987,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
November 1981,
British medical journal (Clinical research ed.),
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
October 1985,
Tumori,
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
November 1985,
The New England journal of medicine,
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
December 1985,
Wiener medizinische Wochenschrift (1946),
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
February 1981,
The Australian and New Zealand journal of surgery,
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
April 1985,
American journal of clinical oncology,
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
December 1985,
Cancer,
A Lipton, and
R J Santen, and
H A Harvey, and
A Manni, and
M A Simmonds, and
D White-Hershey, and
M J Bartholomew, and
B K Walker, and
R H Dixon, and
D E Valdevia
October 1992,
Gan to kagaku ryoho. Cancer & chemotherapy,
