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Fifty postmenopausal women with advanced breast cancer were included in the following randomized phase II trial: 25 patients received aminoglutethimide 1000 mg and hydrocortisone 40 mg daily. Twenty-five patients received aminoglutethimide 1000 mg, hydrocortisone 40 mg and fluoxymesterone 20 mg daily. The two groups of patients were comparable in respect to the most important pretreatment characteristics. The majority of patients in both groups had bone lesions. There was a history of response to tamoxifen in all the cases and 17 patients had positive estrogen and progesterone receptors. The evaluation of response was based on the system adopted by the UICC. In the aminoglutethimide-hydrocortisone group, 16 (64%) patients obtained a partial remission, 3 (12%) remained stable and 6 (24%) had progressive disease. In the combination treatment group, 17 (68%) patients obtained a partial remission, 3 (12%) remained stable and 5 (20%) developed progressive disease. The median duration of partial remission and stabilization of the disease was 9 and 7 months respectively in both groups.
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
January 1988,
Oncology,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
September 1981,
The New England journal of medicine,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
January 1986,
Breast cancer research and treatment,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
June 1986,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
November 1981,
British medical journal (Clinical research ed.),
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
April 1984,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
July 1989,
European journal of cancer & clinical oncology,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
December 1982,
Cancer,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
August 1982,
Cancer research,
C S Gennatas, and
A Kalovidouris, and
G A Paraskevas, and
J Kouvaris, and
D Trichopoulos, and
C Papavasiliou
February 1987,
American journal of clinical oncology,
