BIOMAT Database Logo BIOMAT Database Logo

Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents. 2020

Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Department of Chemistry and Biochemistry, Jackson State University Jackson Mississippi 39217 USA prasanta.das@jsums.edu +1-601-203-5149.

Electrophilic fluorine-mediated dearomative spirocyclization has been developed to synthesize a range of fluoro-substituted spiro-isoxazoline ethers and lactones. The in vitro biological assays of synthesized compounds were probed for anti-viral activity against human cytomegalovirus (HCMV) and cytotoxicity against glioblastomas (GBM6) and triple negative breast cancer (MDA MB 231). Interestingly, compounds 4d and 4n showed significant activity against HCMV (IC50 ∼ 10 μM), while 4l and 5f revealed the highest cytotoxicity with IC50 = 36 to 80 μM. The synthetic efficacy and biological relevance offer an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.

UI MeSH Term Description Entries

Related Publications

Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Synthesis and Investigation of Novel Spiro-isoxazolines as Anti-Cancer Agents.
April 2015, Tetrahedron letters,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Synthesis, biological evaluation and molecular docking of some substituted pyrazolines and isoxazolines as potential antimicrobial agents.
May 2015, European journal of medicinal chemistry,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
N-Substituted Aryl Sulphonamides as Potential Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.
January 2018, Current computer-aided drug design,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Design, synthesis and biological evaluation of substituted flavones and aurones as potential anti-influenza agents.
January 2020, Bioorganic & medicinal chemistry,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents.
April 2018, European journal of medicinal chemistry,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Oxonium Ion Mediated Synthesis of 4-Substituted Spiro-Isoxazolines.
February 2009, Tetrahedron letters,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
2-Azetidinones: Synthesis and biological evaluation as potential anti-breast cancer agents.
November 2016, European journal of medicinal chemistry,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents.
January 2019, Bioorganic & medicinal chemistry,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Synthesis and biological evaluation of isoprenylated coumarins as potential anti-pancreatic cancer agents.
October 2014, Bioorganic & medicinal chemistry letters,
Prasanta Das, and Sarah Boone, and Dipanwita Mitra, and Lindsay Turner, and Ritesh Tandon, and Drazen Raucher, and Ashton T Hamme
Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.
August 2012, European journal of medicinal chemistry,
Copied contents to your clipboard!