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In a double-blind crossover trial conducted on a multicentre basis, 109 patients with "classic" or "definite" rheumatoid arthritis were treated for two weeks with diclofenac sodium (Voltaren, 25 mg t.i.d.) and indomethacin (25 mg t.i.d). Both drugs led to a clear-cut decrease in morning stiffness, as well as to a significant improvement in pain at rest and on movement. In these respects no significant difference between the two-drugs was observed. As regards their effect on status of rheumatoid condition, however, a trend towards a significant improvement was discernible, in the investigator's opinion, only in response to diclofenac sodium. "Unwanted effects" were mentioned by 25 patients before the trial, by 31 during treatment with diclofenac sodium, and by 33 during treatment with indomethacin. While the patients were receiving indomethacin, five of them discontinued treatment on account of side effects (headache in three cases, headache and tiredness in one case, and an allergic skin reaction in one case) and one of them, who complained of headache, lowered the dosage; treatment with diclofenac sodium was discontinued because of side effects by only one patient, who had developed an allergic skin reaction.
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1980,
Scandinavian journal of rheumatology. Supplement,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1978,
Scandinavian journal of rheumatology. Supplement,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
June 1976,
International journal of clinical pharmacology and biopharmacy,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1978,
Scandinavian journal of rheumatology. Supplement,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1979,
Rheumatology and rehabilitation,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1981,
The British journal of clinical practice,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1976,
La Prensa medica mexicana,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1978,
Terapevticheskii arkhiv,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
January 1983,
Arzneimittel-Forschung,
O Mutru, and
M Penttilä, and
J Pesonen, and
P Salmela, and
O Suhonen, and
T Sonck
October 1974,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
