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A five-centre double-blind crossover trial of two two-week periods using diclofenac and indomethacin showed that both drug groups (51 patients) with rheumatoid arthritis responded similarly in relation to pain scores and morning stiffness. It was noted that the response was better in inpatients than in outpatients, despite differences in disease severity. In the osteoarthritis trial (58 patients) it was shown that neither drug significantly reduced resting pain, although both drugs were significantly better in reducing pain on movement; however, patient preference was for diclofenac. Three patients treated with indomethacin withdrew owing to side-effects, compared with one on diclofenac. A slight but significant decrease in haemoglobin levels was observed in both treatment groups with osteoarthritis, but this did not appear to be symptom-related.
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
January 1979,
Rheumatology and rehabilitation,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
January 1979,
Rheumatology and rehabilitation,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
January 1978,
Scandinavian journal of rheumatology. Supplement,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
January 1979,
Rheumatology and rehabilitation,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
November 1979,
International journal of clinical pharmacology and biopharmacy,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
January 1976,
La Prensa medica mexicana,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
May 1978,
Rheumatology and rehabilitation,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
January 1979,
Rheumatology and rehabilitation,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
November 1985,
Seminars in arthritis and rheumatism,
C G Barnes, and
H Berry, and
M E Carter, and
W W Downie, and
P D Fowler, and
J M Moll, and
J D Perry, and
M S Sawaf, and
V Wright
January 1979,
Rheumatology and rehabilitation,
