Biomaterial Database

The effect of ephedrine upon uterine artery blood flow velocity in the pregnant guinea pig subjected to terbutaline infusion and acute hemorrhage. 1987

D H Chestnut, and C P Weiner, and J P Wang, and J E Herrig, and J G Martin

The purpose of the present study was to determine the effect of intravenously administered ephedrine upon uterine artery blood flow velocity (UBFV) in the gravid guinea pig subjected to terbutaline infusion and acute hemorrhage. Ephedrine, 1.0 mg/kg, was administered intravenously to ten chronically instrumented pregnant guinea pigs near term, before and after intravenous infusion of terbutaline and acute hemorrhage. Before terbutaline and hemorrhage, ephedrine increased maternal mean arterial pressure (MMAP) by 30 +/- 1% (P = .0001) and 17 +/- 1% (P = .0001) at 30 s and at 1 min after injection, respectively; UBFV was decreased by 10 +/- 4% (P less than .01) and 14 +/- 4% (P less than .01) at 1 min and at 90 s after injection, respectively. Infusion of terbutaline (1.5-6.0 ug X kg-1 X min-1) increased maternal heart rate (MHR) by 22 +/- 1% (P = .0001), decreased MMAP by 13 +/- 2% (P = .0001), and decreased UBFV by 24 +/- 3% (P = .0001). During hypotension resulting from acute hemorrhage, ephedrine, 1.0 mg/kg, was superior to placebo in restoring MMAP and UBFV toward the prebleed values. The authors concluded that ephedrine, 1.0 mg/kg, results in a small, transient decrease in UBFV in the normotensive gravid guinea pig. However, ephedrine aids restoration of UBFV in the gravid guinea pig rendered hypotensive by acute hemorrhage during terbutaline infusion.

UI	MeSH Term	Description	Entries
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D001783	Blood Flow Velocity	A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.	Blood Flow Velocities,Flow Velocities, Blood,Flow Velocity, Blood,Velocities, Blood Flow,Velocity, Blood Flow
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004809	Ephedrine	A phenethylamine found in EPHEDRA SINICA. PSEUDOEPHEDRINE is an isomer. It is an alpha- and beta-adrenergic agonist that may also enhance release of norepinephrine. It has been used for asthma, heart failure, rhinitis, and urinary incontinence, and for its central nervous system stimulatory effects in the treatment of narcolepsy and depression. It has become less extensively used with the advent of more selective agonists.	Ephedrine Hydrochloride,Ephedrine Renaudin,Ephedrine Sulfate,Erythro Isomer of Ephedrine,Sal-Phedrine,Ephedrine Erythro Isomer,Hydrochloride, Ephedrine,Renaudin, Ephedrine,Sal Phedrine,SalPhedrine,Sulfate, Ephedrine
D005260	Female		Females
D006224	Cricetinae	A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.	Cricetus,Hamsters,Hamster
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006470	Hemorrhage	Bleeding or escape of blood from a vessel.	Bleeding,Hemorrhages
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013726	Terbutaline	A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.	Arubendol,Asthmoprotect,Brethaire,Brethine,Bricanyl,Bricanyl SA,Butaliret,Butalitab,Contimit,KWD-2019,Monovent,Taziken,Tedipulmo,Terbasmin,Terbul,Terbutalin AL,Terbutalin Stada,Terbutalin-ratiopharm,Terbutaline Sulfate,Terbuturmant,terbutalin von ct,KWD 2019,KWD2019,Terbutalin ratiopharm