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The effect of terbutaline sulphage, a beta-adrenergic agonist, on uteroplacental blood flow was studied in the guinea pig during late pregnancy. Organ blood flows and cardiac output were assessed by the radioactive microsphere technique. Infusion of terbutaline at a rate of 2nmol min-1 kg-1 body weight caused a significant increase in cardiac output and in the perfusion of the uterus and ovaries, but there was no significant alteration in maternal placental blood flow. When the infusion rate was increased tenfold, there was also a significant rise in the blood supply to the bronchi, urinary bladder, kidneys, and adrenal glands. Maternal placental blood flow was not adversely affected even by this large dose of the drug, although there was a significant reduction in the placental share of the cardiac output.
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
June 1975,
Zeitschrift fur Geburtshilfe und Perinatologie,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
January 1976,
Advances in experimental medicine and biology,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
March 1978,
The British journal of nutrition,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
April 1984,
Endocrinology,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
April 1987,
Anesthesiology,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
January 1974,
Journal of perinatal medicine,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
February 1976,
Zeitschrift fur Geburtshilfe und Perinatologie,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
December 1973,
Diabetologia,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
December 1986,
Anesthesiology,
L Mårtensson, and
P O Sjöquist, and
L Bjellin, and
A M Carter
September 1982,
The American journal of physiology,
