Mineralogical analysis of bronchoalveolar lavage in talc pneumoconiosis. 1987

P de Vuyst, and P Dumortier, and P Léophonte, and R V Weyer, and J C Yernault

Bronchoalveolar lavage (BAL) fluid obtained from six talc workers with pneumoconiosis was studied by optical and electron microscopy for its mineral content. Two of these workers were mainly exposed to American and Australian talc, and the other four were exposed to French talc (Luzenac). In all lavage fluids, talc particles and talc bodies were abundant, sometimes many years after the end of exposure. A qualitative difference was the presence of tremolite asbestos fibres in the two patients exposed to American and Australian talc and its absence in the four French talc workers. The presence of tremolite in lavage is attributed to a geological association of this mineral with the inhaled talc. On the other hand, chlorite was abundant in BAL of the French talc workers. Hence, we suggest that bronchoalveolar lavage can confirm exposure to talc and provide information about the heterogeneity of inhaled dust.

UI MeSH Term Description Entries
D007507 Therapeutic Irrigation The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis. Douching,Lavage,Douchings,Irrigation, Therapeutic,Irrigations, Therapeutic,Lavages,Therapeutic Irrigations
D008853 Microscopy The use of instrumentation and techniques for visualizing material and details that cannot be seen by the unaided eye. It is usually done by enlarging images, transmitted by light or electron beams, with optical or magnetic lenses that magnify the entire image field. With scanning microscopy, images are generated by collecting output from the specimen in a point-by-point fashion, on a magnified scale, as it is scanned by a narrow beam of light or electrons, a laser, a conductive probe, or a topographical probe. Compound Microscopy,Hand-Held Microscopy,Light Microscopy,Optical Microscopy,Simple Microscopy,Hand Held Microscopy,Microscopy, Compound,Microscopy, Hand-Held,Microscopy, Light,Microscopy, Optical,Microscopy, Simple
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011009 Pneumoconiosis A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population. Bagassosis,Pneumoconioses
D011650 Pulmonary Alveoli Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place. Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001194 Asbestos Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
D013627 Talc Finely powdered native hydrous magnesium silicate. It is used as a dusting powder, either alone or with starch or boric acid, for medicinal and toilet preparations. It is also an excipient and filler for pills, tablets, and for dusting tablet molds. (From Merck Index, 11th ed) Talcum Powder

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