Spectral and temporal response patterns of single units in the chinchilla dorsal cochlear nucleus. 1987

J A Kaltenbach, and J C Saunders

Spectral and temporal response patterns to pure-tone stimuli were collected from single units in the dorsal cochlear nucleus of anesthetized chinchillas. The spectral response profiles were divisible into groups based on the balance of excitation and inhibition. Temporal responses were characterized in chloralose-anesthetized animals by collecting PST-histograms. There appeared to be no simple one-to-one relationship between a unit's spectral and its temporal response pattern. Excitatory spectral responses were generally sharply tuned areas resembling those of auditory nerve fibers. However, unlike the latter, the majority of these had chopper or pauser/buildup temporal responses. Inhibitory spectral responses were of two distinct types: one included lateral inhibitory areas flanking the tuned excitatory areas which occasionally invaded the latter creating a nonmonotonic excitatory response at the unit's characteristic frequency. The other included sharply tuned inhibitory areas. The characteristic frequencies of these units were found to be in close correspondence with those of sharply tuned excitatory units from the same penetration suggesting that these inhibitory units were tonotopically mapped in the same register as tuned excitatory units. The spectral response patterns were studied with three types of anesthesia: ketamine/xylazine, dial/urethane, and chloralose. In each of these groups the patterns were similar. However, the proportions of units showing inhibition was strongly dependent on the choice of anesthetic agent with chloralose yielding the highest proportions (59%) and ketamine/xylazine yielding the lowest (29%).

UI MeSH Term Description Entries
D008526 Medulla Oblongata The lower portion of the BRAIN STEM. It is inferior to the PONS and anterior to the CEREBELLUM. Medulla oblongata serves as a relay station between the brain and the spinal cord, and contains centers for regulating respiratory, vasomotor, cardiac, and reflex activities. Accessory Cuneate Nucleus,Ambiguous Nucleus,Arcuate Nucleus of the Medulla,Arcuate Nucleus-1,External Cuneate Nucleus,Lateral Cuneate Nucleus,Nucleus Ambiguus,Ambiguus, Nucleus,Arcuate Nucleus 1,Arcuate Nucleus-1s,Cuneate Nucleus, Accessory,Cuneate Nucleus, External,Cuneate Nucleus, Lateral,Medulla Oblongatas,Nucleus, Accessory Cuneate,Nucleus, Ambiguous,Nucleus, External Cuneate,Nucleus, Lateral Cuneate
D009433 Neural Inhibition The function of opposing or restraining the excitation of neurons or their target excitable cells. Inhibition, Neural
D002682 Chinchilla A genus of the family Chinchillidae which consists of three species: C. brevicaudata, C. lanigera, and C. villidera. They are used extensively in biomedical research. Chinchillas
D000200 Action Potentials Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli. Spike Potentials,Nerve Impulses,Action Potential,Impulse, Nerve,Impulses, Nerve,Nerve Impulse,Potential, Action,Potential, Spike,Potentials, Action,Potentials, Spike,Spike Potential
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001306 Auditory Pathways NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX. Auditory Pathway,Pathway, Auditory,Pathways, Auditory
D012684 Sensory Thresholds The minimum amount of stimulus energy necessary to elicit a sensory response. Sensory Threshold,Threshold, Sensory,Thresholds, Sensory

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