-transparent.png){kind=logo}
The effect of bombesin on insulin release from isolated pancreatic islets of rats was examined in vitro. Bombesin, at the doses ranging from 10 ng/ml to 1 microgram/ml, significantly inhibited 16.7 mM glucose-induced insulin release, while bombesin had no inhibitory effect on insulin release at 8.3 mM and 3.3 mM glucose. Moreover, bombesin also suppressed insulin release elicited by 10 mM arginine at the doses of 100 ng/ml and 1 microgram/ml. These results indicate that bombesin has a direct inhibitory action on insulin release.
Related Publications
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
August 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
April 1989,
Journal of endocrinological investigation,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
August 1980,
Diabetologia,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
May 1970,
Science (New York, N.Y.),
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
March 1989,
Endocrinology,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
April 1969,
Diabetologia,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
January 1986,
Diabetes,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
June 1975,
FEBS letters,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
January 1992,
Diabete & metabolisme,
T Taminato, and
Y Seino, and
Y Goto, and
S Matsukura, and
H Imura, and
N Sakura, and
N Yanaihara
September 1977,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
