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This report describes the synthesis of L- and D-[methyl-11C]methionine in pure enantiomeric forms. The compounds were prepared routinely approximately 1,000 times with less than 20 failures. Starting with carbon-11 (11C) methyl iodide, a simple one-carbon precursor produced from a one-pot or a two-pot apparatus, L- and D-[methyl-11C]methionine were prepared, respectively, with an optical purity higher than 99% in 40%-90% radiochemical yields. The total time for synthesis, starting from [11C]carbon dioxide, was 12-15 min. The crude product usually had a radiochemical purity greater than 95%. The total time for synthesis, including LC purification, was 20-30 min. The radiochemical purity of the product in each case was greater than 98%.
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 1987,
Neuroradiology,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 1988,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
July 1976,
The International journal of applied radiation and isotopes,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
August 1988,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 1987,
Acta radiologica (Stockholm, Sweden : 1987),
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 1988,
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 1985,
Journal of computer assisted tomography,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 1987,
European journal of nuclear medicine,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 1991,
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes,
B Långström, and
G Antoni, and
P Gullberg, and
C Halldin, and
P Malmborg, and
K Någren, and
A Rimland, and
H Svärd
January 2019,
Methods in molecular biology (Clifton, N.J.),
