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In homogenates and subcellular fractions of pancreatic islets of Wistar rats we could demonstrate three groups of protein degrading enzymes. The proteinases of group 1 are characterized by both trypsin-like and carboxypeptidase B-like specificities with slightly acid pH optima (pH 5.5-6.5) and seem to play important roles in the conversion of proinsulin into insulin. The properties suggest that these enzymes localized in the secretion granule/mitochondria fraction are related to the tissue cathepsins. Group 2 enzymes are thiol-depending proteinases with a pH optimum at 7.0 occuring mainly in the cytosol and to a lesser extent in the fraction of nuclei and cell debris. Group 3 represents the thiol protein oxidoreductase with a pH optimum of 7.0. This enzyme degrading disulfide bonds could also be important in the formation of the disulfide bonds during protein folding after synthesis.
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
May 1972,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
April 1975,
Diabetes,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
January 1976,
Ciba Foundation symposium,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
February 1965,
Endocrinology,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
January 2016,
General physiology and biophysics,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
July 1977,
Nihon Naibunpi Gakkai zasshi,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
January 1995,
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
September 1988,
Diabetes,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
June 1978,
Endocrinologia japonica,
H Zühlke, and
K D Kohnert, and
H Jahr, and
S Schmidt, and
H Kirschke, and
D F Steiner
January 1981,
Zeitschrift fur experimentelle Chirurgie,
