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The use of unilateral lobar bronchoalveolar lavage (BAL) to assess disease activity in pulmonary sarcoidosis assumes that the alveolitis is homogeneous throughout the lung parenchyma. Three studies were used to evaluate this premise in 21 patients with sarcoidosis who had a broad range of abnormalities: bilateral BAL cell counts, quantitated regional gallium-67 lung uptake, and analysis of chest radiographs. Based on results of these studies, we conclude that the alveolitis in sarcoidosis is homogeneous in the majority of patients, although lavage of the lingula may give erroneous results due to the frequently increased proportion of neutrophils. The only moderate level of correlation between the BAL % lymphocytes and gallium-67 lung uptake, even when the same regions of the lung are studied, suggests that these tests may measure different aspects of disease activity.
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
January 1986,
Annals of the New York Academy of Sciences,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
April 1981,
The American review of respiratory disease,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
May 1984,
Chest,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
January 1985,
Revue de pneumologie clinique,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
May 1984,
Medicina clinica,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
January 1987,
Revue des maladies respiratoires,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
January 1982,
Thorax,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
January 1986,
Zeitschrift fur Erkrankungen der Atmungsorgane,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
November 1982,
Chest,
G W Staton, and
I J Check, and
W A Fajman, and
M J Gilman, and
J R Pine
July 1986,
Casopis lekaru ceskych,
