-transparent.png){kind=logo}
Although the three distinct forms of protein kinase C isolated from rat brain soluble fraction are structurally very similar, they respond differently to free unsaturated fatty acids such as arachidonic acid to exhibit their catalytic activity. Type I enzyme encoded by gamma-sequence, as predicted by cDNA clone analysis, responds to these fatty acids only slightly, whereas Type III enzyme determined by alpha-sequence is activated by free unsaturated fatty acids in the presence of Ca2+ in a comparable manner to phosphatidylserine plus diacylglycerol. Type II, a mixture of two enzymes encoded by beta I- and beta II-sequence, resulting from alternative splicing, shows properties in between those of Type I and Type III. Some of these forms of protein kinase C may function at a relatively later phase of cellular responses when large amounts of unsaturated fatty acids and Ca2+ are mobilized.
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
November 1993,
Biochemical Society transactions,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
September 1995,
Clinical immunology and immunopathology,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
September 1993,
Biochemical and biophysical research communications,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
February 1989,
The Biochemical journal,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
August 1989,
The Kobe journal of medical sciences,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
March 1995,
Journal of biochemistry,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
November 1988,
Molecular endocrinology (Baltimore, Md.),
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
May 2007,
Journal of lipid research,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
June 1989,
The Kobe journal of medical sciences,
K Sekiguchi, and
M Tsukuda, and
K Ogita, and
U Kikkawa, and
Y Nishizuka
April 1994,
Journal of neurochemistry,
