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We have studied the effects of 2,3-diphosphoglycerate (2,3-DPG), 3-phosphoglycerate (3-PG), 3-phosphoglyceraldehyde (3-PGA), 2-phosphoglycerate (2-PG) and beta-glycerol phosphate (beta-GP) on platelet aggregation and on thromboxane B2 (TXB2) formation. The results show that 2,3-DPG, 3-PG, and 3-PGA inhibited platelet aggregation and TXB2 formation induced by norepinephrine, ADP, epinephrine, and collagen; but they also induced platelet aggregation and TXB2 formation in the presence of subthreshold concentrations of Na arachidonate. 2-PG and beta-GP were inactive. The results also show that there is a structure-function relationship between 2,3-DPG, 3-PG, and 3-PGA with platelet aggregation phenomena and prostaglandin synthesis.
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
January 1978,
Pharmacological research communications,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
January 1985,
Nature,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
November 2008,
Journal of thrombosis and haemostasis : JTH,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
July 1991,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
January 1980,
Advances in prostaglandin and thromboxane research,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
January 1979,
Rinsho byori. The Japanese journal of clinical pathology,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
November 1980,
Biochemical and biophysical research communications,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
October 1988,
Biochemical and biophysical research communications,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
December 1996,
Anesthesiology,
P G Iatridis, and
H Hadd, and
M Kotrotsou, and
L Ling-Indeck, and
S G Iatridis
June 1979,
Proceedings of the National Academy of Sciences of the United States of America,
