-transparent.png){kind=logo}
To study the effect of zinc deficiency on folate metabolism, three groups of male Sprague-Dawley rats (zinc deficient (ZD), restricted-fed (RF + Zn), and ad libitum-fed control (control] were given a semipurified 25% egg white protein diet. The ZD group received less than 10.3 nmol zinc/g of diet, while the RF + Zn and control groups were given 1620 nmol zinc/g of diet. After 6-7 weeks of feeding, severe zinc deficiency developed in ZD rats. Hepatic methionine synthetase activity was increased in the ZD group compared to both the RF + Zn and control groups, but hepatic 5,10-CH2-H4folate reductase activity was similar in all groups. This increased methionine synthetase activity found in zinc-deficient rats might induce secondary alterations in folate metabolism. These changes include significantly lowered plasma folate levels, decreased 5-CH3-H4folate in liver, and increased rates of histidine and formate oxidation. The latter two findings suggest that the available non-5-CH3-H4folate is increased in zinc deficiency.
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
July 1984,
Anesthesiology,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
April 2000,
Biochemical and biophysical research communications,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
January 1987,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
January 1963,
Acta Universitatis Carolinae. Medica,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
January 1987,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
October 1986,
Chemico-biological interactions,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
October 1975,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
April 1999,
Lipids,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
February 1991,
The Biochemical journal,
T Tamura, and
L L Kaiser, and
J E Watson, and
C H Halsted, and
L S Hurley, and
E L Stokstad
May 1977,
The Journal of nutrition,
