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Chloride is the most common counterion used to improve aqueous solubility and enhance stability of small molecule active pharmaceutical ingredients. While several analytical techniques, such as titration, HPLC with charged aerosol detection, and ion chromatography, are currently utilized to assay the level of chloride, they have notable limitations, and these instruments may not be readily available. Here, we present a generally applicable 35 Cl solution NMR method to assay the level of chloride in pharmaceutical compounds. The method uses KClO4 as an internal standard for improved accuracy in comparison with external standard methods, and it was found to be robust, linear over three orders of magnitude, precise (<3% RSD), and accurate (<0.5% absolute error).
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
February 2014,
Yao xue xue bao = Acta pharmaceutica Sinica,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
January 2018,
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
October 2020,
Analytical and bioanalytical chemistry,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
September 2017,
Talanta,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
October 2023,
Analytical chemistry,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
July 1984,
Nihon saikingaku zasshi. Japanese journal of bacteriology,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
September 2002,
Analytical biochemistry,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
January 1978,
Neuroradiology,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
July 1964,
Chemical & pharmaceutical bulletin,
Jared S Wood, and
Guilherme Dal Poggetto, and
Xiao Wang, and
Mikhail Reibarkh, and
R Thomas Williamson, and
Ryan D Cohen
November 2013,
Magnetic resonance in chemistry : MRC,
