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After a control period on a placebo, 45 patients with mild to moderate hypertension were treated with metoprolol, 100 mg twice daily alone and in free combination with chlorthalidone 50 mg daily using a double-blind crossover technique. The beta-blocker alone induced a significant fall in blood pressure; the diastolic pressure was reduced to 100 mg Hg or less in 37 of the 45 patients and to 95 mm Hg or less in 19 patients. The addition of chlorthalidone enhanced the antihypertensive effect so that in 33 patients diastolic pressure fell to 95 mm Hg or less. The drugs were well tolerated even by a small number of patients with chronic bronchitis and diabetes mellitus. None of the patients developed cardiac failure. Adding a diuretic caused a small reduction in serum potassium concentrations, and the relevance of this observation is discussed.
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
April 1983,
Scottish medical journal,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
December 2017,
Journal of clinical hypertension (Greenwich, Conn.),
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
December 1981,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
August 1981,
Arquivos brasileiros de cardiologia,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
December 1984,
International journal of clinical pharmacology, therapy, and toxicology,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
March 1961,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
July 1965,
Revista brasileira de medicina,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
February 2022,
Advances in therapy,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
July 1962,
Revista espanola de cardiologia,
M Kubik, and
M Kendall, and
A Ebbutt, and
V John
October 1986,
Minerva cardioangiologica,
