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Seroprevalence of Measles Antibodies in a Highly MMR-Vaccinated Population. 2022

Huy Quang Quach, and Inna G Ovsyannikova, and Diane E Grill, and Nathaniel D Warner, and Gregory A Poland, and Richard B Kennedy
Mayo Clinic Vaccine Research Group, Division of General of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.

As an extremely contagious pathogen, a high rate of vaccine coverage and the durability of vaccine-induced immunity are key factors to control and eliminate measles. Herein, we assessed the seroprevalence of antibodies specific to measles in a cohort of 1393 adults (20-44 years old). ELISA results showed a nontrivial proportion of 37.6% study subjects being negative for measles immunoglobulin G (IgG). We also found significant influences of sex and age of the study cohort on the IgG level. Our findings suggest that even within a highly vaccinated population, a subset of individuals may still have sub-optimal immunity against measles and potentially be susceptible during any future measles outbreaks.

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