-transparent.png){kind=logo}
Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease. 2022
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some patients but deteriorated in others. This could be explained by variance in electrode placement leading to differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on a multi-center cohort of 46 patients with DBS to the fornix (NCT00658125, NCT01608061). Using normative structural and functional connectivity data, we found that stimulation of the circuit of Papez and stria terminalis robustly associated with cognitive improvement (R = 0.53, p < 0.001). On a local level, the optimal stimulation site resided at the direct interface between these structures (R = 0.48, p < 0.001). Finally, modulating specific distributed brain networks related to memory accounted for optimal outcomes (R = 0.48, p < 0.001). Findings were robust to multiple cross-validation designs and may define an optimal network target that could refine DBS surgery and programming.
Related Publications
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
April 2022,
Proceedings of the National Academy of Sciences of the United States of America,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
August 2019,
The New England journal of medicine,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
August 2016,
Neurosurgery,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
August 2022,
Ageing research reviews,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
September 2016,
Journal of Alzheimer's disease : JAD,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
July 2016,
Journal of neurosurgery,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
December 2023,
Biological psychiatry,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
August 2023,
European journal of clinical investigation,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
January 2017,
Current Alzheimer research,
Ana Sofía Ríos, and
Simón Oxenford, and
Clemens Neudorfer, and
Konstantin Butenko, and
Ningfei Li, and
Nanditha Rajamani, and
Alexandre Boutet, and
Gavin J B Elias, and
Jurgen Germann, and
Aaron Loh, and
Wissam Deeb, and
Fuyixue Wang, and
Kawin Setsompop, and
Bryan Salvato, and
Leonardo Brito de Almeida, and
Kelly D Foote, and
Robert Amaral, and
Paul B Rosenberg, and
David F Tang-Wai, and
David A Wolk, and
Anna D Burke, and
Stephen Salloway, and
Marwan N Sabbagh, and
M Mallar Chakravarty, and
Gwenn S Smith, and
Constantine G Lyketsos, and
Michael S Okun, and
William S Anderson, and
Zoltan Mari, and
Francisco A Ponce, and
Andres M Lozano, and
Andreas Horn
January 2018,
Journal of Alzheimer's disease : JAD,
