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1. Calcium depletion from the medium of the isolated perfused kidney reduced renin release and renal perfusate flow. 2. Reintroduction of calcium increased renin release and perfusate flow. 3. The ionophore X 537 A (0.1-4 micromol/1) increased renin release both in the presence and absence of calcium in the medium. 4. The ionophore A 23187 (1-10 nmol/1) increased as well as decreased renin release. There was a positive correlation between direction of this effect and renal perfusate flow. 5. The results are compatible with the view that the effects of calcium and ionophores on renin release are the sum of direct and indirect effects of these agents, the predominant indirect effect being the modification of vascular tone.
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
September 1979,
Experientia,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
January 1981,
Brain research,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
January 1975,
Naunyn-Schmiedeberg's archives of pharmacology,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
March 1987,
Japanese heart journal,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
July 1983,
Kidney international,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
January 1975,
Life sciences,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
January 1972,
Investigative urology,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
October 1978,
Pflugers Archiv : European journal of physiology,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
January 1986,
Renal physiology,
U Schwertschlag, and
E Hackenthal, and
R Hackenthal, and
G H Rohs
October 1985,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
