Biomaterial Database

Acoustic reflex dynamics and auditory brain stem responses in multiple sclerosis. 1987

R W Keith, and Y Garza-Holquin, and L Smolak, and M L Pensak

Department of Otolaryngology, University of Cincinnati Medical Center, OH 45267-0528.

Onset latency, rise time, and amplitude measures of the acoustic reflex and auditory brain stem responses (ABRs) to clicks were elicited from normal subjects and subjects with multiple sclerosis (MS). The results indicated that MS subjects exhibited response abnormalities including prolonged rise times of the acoustic reflex and prolonged absolute latencies, interwave latencies and interaural latencies, and poor response stability of the ABR. The results of this study indicate that measurement of acoustic reflex dynamics can add to the diagnostic value of the test beyond measurement of acoustic reflex threshold and decay. The combination of complete acoustic reflex and ABR tests is a valuable contribution to the diagnosis of patients with MS who have no auditory symptoms.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009103	Multiple Sclerosis	An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)	MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D012022	Reflex, Acoustic	Intra-aural contraction of tensor tympani and stapedius in response to sound.	Acoustic Reflex
D001933	Brain Stem	The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.	Brainstem,Truncus Cerebri,Brain Stems,Brainstems,Cerebri, Truncus,Cerebrus, Truncus,Truncus Cerebrus
D005072	Evoked Potentials, Auditory	The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.	Auditory Evoked Potentials,Auditory Evoked Response,Auditory Evoked Potential,Auditory Evoked Responses,Evoked Potential, Auditory,Evoked Response, Auditory,Evoked Responses, Auditory,Potentials, Auditory Evoked
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001301	Audiometry, Pure-Tone	Measurement of hearing based on the use of pure tones of various frequencies and intensities as auditory stimuli.	Audiometry, Bekesy,Audiometry, Pure Tone,Bekesy Audiometry,Pure-Tone Audiometry
D001304	Auditory Diseases, Central	Disorders of hearing or auditory perception due to pathological processes of the AUDITORY PATHWAYS in the CENTRAL NERVOUS SYSTEM. These include CENTRAL HEARING LOSS and AUDITORY PERCEPTUAL DISORDERS.	Auditory Cortex Disorder,Central Auditory Diseases,Auditory Dysfunction, Central,Auditory Pathway Disorders, Central,Central Auditory Pathway Disorders,Auditory Cortex Disorders,Auditory Disease, Central,Central Auditory Disease,Central Auditory Dysfunction,Cortex Disorder, Auditory,Cortex Disorders, Auditory,Dysfunction, Central Auditory,Dysfunctions, Central Auditory
D001306	Auditory Pathways	NEURAL PATHWAYS and connections within the CENTRAL NERVOUS SYSTEM, beginning at the hair cells of the ORGAN OF CORTI, continuing along the eighth cranial nerve, and terminating at the AUDITORY CORTEX.	Auditory Pathway,Pathway, Auditory,Pathways, Auditory