BIOMAT Database Logo BIOMAT Database Logo

Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1-Parkin-mediated mitophagy in allergic rhinitis. 2023

Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji, P.R. China.

Polydatin (PD), a natural product derived from Polygonum cuspidatum, has anti-inflammatory and antioxidant effects and has significant benefits in treating allergic diseases. However, its role and mechanism in allergic rhinitis (AR) have not been fully elucidated. Herein, we investigated the effect and mechanism of PD in AR. AR model was established in mice with OVA. Human nasal epithelial cells (HNEpCs) were stimulated with IL-13. HNEpCs were also treated with an inhibitor of mitochondrial division or transfected with siRNA. The levels of IgE and cellular inflammatory factors were examined by enzyme linked immunosorbent assay and flow cytometry. The expressions of PINK1, Parkin, P62, LC3B, NLRP3 inflammasome proteins, and apoptosis proteins in nasal tissues and HNEpCs were measured by Western blot. We found that PD suppressed OVA-induced epithelial thickening and eosinophil accumulation in the nasal mucosa, reduced IL-4 production in NALF, and regulated Th1/Th2 balance. In addition, mitophagy was induced in AR mice after OVA challenge and in HNEpCs after IL-13 stimulation. Meanwhile, PD enhanced PINK1-Parkin-mediated mitophagy but decreased mitochondrial reactive oxygen species (mtROS) production, NLRP3 inflammasome activation, and apoptosis. However, PD-induced mitophagy was abrogated after PINK1 knockdown or Mdivi-1 treatment, indicating a key role of the PINK1-Parkin in PD-induced mitophagy. Moreover, mitochondrial damage, mtROS production, NLRP3 inflammasome activation, and HNEpCs apoptosis under IL-13 exposure were more severe after PINK1 knockdown or Mdivi-1 treatment. Conclusively, PD may exert protective effects on AR by promoting PINK1-Parkin-mediated mitophagy, which further suppresses apoptosis and tissue damage in AR through decreasing mtROS production and NLRP3 inflammasome activation.

UI MeSH Term Description Entries
D011494 Protein Kinases A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein. Protein Kinase,Kinase, Protein,Kinases, Protein
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071199 NLR Family, Pyrin Domain-Containing 3 Protein An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME. Cold Autoinflammatory Syndrome 1 Protein,NACHT, LRR and PYD Domains-Containing Protein 3,NLRP3 Protein,NACHT, LRR and PYD Domains Containing Protein 3,NLR Family, Pyrin Domain Containing 3 Protein
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017382 Reactive Oxygen Species Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of SIGNAL TRANSDUCTION and GENE EXPRESSION, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS. Active Oxygen Species,Oxygen Radical,Oxygen Radicals,Pro-Oxidant,Reactive Oxygen Intermediates,Active Oxygen,Oxygen Species, Reactive,Pro-Oxidants,Oxygen, Active,Pro Oxidant,Pro Oxidants,Radical, Oxygen
D044767 Ubiquitin-Protein Ligases A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes. Ubiquitin-Protein Ligase,E3 Ligase,E3 Ubiquitin Ligase,Ubiquitin Ligase E3,Ubiquitin-Protein Ligase E3,Ligase E3, Ubiquitin,Ligase E3, Ubiquitin-Protein,Ligase, E3,Ligase, E3 Ubiquitin,Ligase, Ubiquitin-Protein,Ligases, Ubiquitin-Protein,Ubiquitin Ligase, E3,Ubiquitin Protein Ligase,Ubiquitin Protein Ligase E3,Ubiquitin Protein Ligases
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D058847 Inflammasomes Multiprotein complexes that mediate the activation of CASPASE-1. Dysregulation of inflammasomes has also been linked to a number of autoinflammatory and autoimmune disorders. Inflammasome,Pyroptosome,Pyroptosomes
D018793 Interleukin-13 A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses. IL-13,IL 13,IL13,Interleukin 13
D063306 Mitophagy Proteolytic breakdown of the MITOCHONDRIA via autophagy. Mitochondrial Degradation

Related Publications

Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
PLIN2 exacerbates Allergic Rhinitis by inhibiting PINK1/Parkin-mediated mitophagy.
November 2025, Immunology letters,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
Bcl-xL inhibits PINK1/Parkin-dependent mitophagy by preventing mitochondrial Parkin accumulation.
May 2020, The international journal of biochemistry & cell biology,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.
November 2025, The EMBO journal,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
Cadmium induces mitophagy through ROS-mediated PINK1/Parkin pathway.
October 2014, Toxicology mechanisms and methods,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
Sam50 Regulates PINK1-Parkin-Mediated Mitophagy by Controlling PINK1 Stability and Mitochondrial Morphology.
June 2018, Cell reports,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
Manganese-induced alpha-synuclein overexpression aggravates mitochondrial damage by repressing PINK1/Parkin-mediated mitophagy.
June 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
PINK1/Parkin-mediated mitophagy inhibits warangalone-induced mitochondrial apoptosis in breast cancer cells.
April 2021, Aging,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
Mitochondrial fumarate inhibits Parkin-mediated mitophagy.
June 2025, Molecular cell,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
Dibutyl phthalate causes MC3T3-E1 cell damage by increasing ROS to promote the PINK1/Parkin-mediated mitophagy.
October 2022, Environmental toxicology,
Siqi Liu, and Chongyang Wang, and Yulian Zhang, and Yalin Zhang, and Yilan Song, and Jingzhi Jiang, and Ruobai Liu, and Hainan Jin, and Guanghai Yan, and Yongde Jin
PINK1/Parkin mediated mitophagy ameliorates palmitic acid-induced apoptosis through reducing mitochondrial ROS production in podocytes.
May 2020, Biochemical and biophysical research communications,
Copied contents to your clipboard!