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Research on antibacterial and antifungal agents. III. Synthesis and antimicrobial activity of 2-methyl-5-aryl-3-furoic acids and 2-methyl-3-imidazolylmethyl-5-aryl furans. 1987
G C Porretta, and
M Scalzo, and
F Chimenti, and
A Bolasco, and
M Biava, and
M Fischetti, and
F Riccardi
Istituto di Chimica Farmaceutica e Tossicologica, Facoltà di Farmacia, Universit La Sapienza, Roma, Italy.
The synthesis and microbiological activities of 2-methyl-5-aryl-3-furoic acids and 2-methyl-3-imidazolyl-methyl-5-aryl-3-furans are reported. Antimicrobial data in comparison with pyrrolnitrin showed an interesting antifungal activity but a very poor antibacterial activity. The presence of an imidazole nucleus does not increase antifungal activity. The introduction of a substituent in the para position of the aryl at a C5 of the furan ring affects antifungal activity.
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