-transparent.png){kind=logo}
Third dose of SARS-CoV2 mRNA vaccination produces robust persistent cellular and humoral immune responses in liver transplant recipients. 2023
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
National Institute for Infectious Diseases L. Spallanzani, IRCCS, Rome, Italy.
Weaker responses have been described after two doses of anti-SARS-CoV2 vaccination in liver transplant recipients (LTRs). At the Italian National Institute for Infectious Diseases, 122 LTRs (84% males, median age 64 years) were tested for humoral and cell-mediated immune response after a third doses of anti-SARS-CoV2 mRNA vaccines. Humoral response was measured by quantifying anti-receptor binding domain and neutralizing antibodies; cell-mediated response was measured by quantifying IFN-γ after stimulation of T cells with SARS-CoV-2-specific peptides. Humoral and cellular responses improved significantly compared to the second vaccine dose; 86.4% of previous non-responders to the first 2 vaccine doses (N = 22) became responders. Mycophenolate mofetil-containing regimens were not associated with lower response rates to a third vaccine; shorter time since transplantation (<6 years) was associated with lower humoral and cellular responses to third vaccine. Protective antibodies against Omicron variant were detected in 60% of patients 12 weeks after third vaccine dose.
Related Publications
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
November 2022,
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
July 2023,
Vaccine,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
April 1980,
Annals of internal medicine,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
February 2024,
Communications medicine,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
October 2009,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
June 2023,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
December 2021,
Vaccines,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
September 2022,
iScience,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
December 2021,
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
Marzia Montalbano, and
Paola Piccolo, and
Raffaella Lionetti, and
Ubaldo Visco-Comandini, and
Chiara Agrati, and
Germana Grassi, and
Silvia Meschi, and
Giulia Matusali, and
Federica Conte, and
Federica Angelone, and
Giuseppe Maria Ettorre, and
Nicola Guglielmo, and
Fabrizio Maggi, and
Massimo Francalancia, and
Tiziana Mereu, and
Vincenzo Puro, and
Enrico Girardi, and
Gianpiero D'Offizi
September 2021,
Vaccines,
