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The immunosuppressive activity of spergualin analogues, 15-deoxyspergualin and N-30, is presented. These compounds suppressed antibody formation and establishment of delayed-type hypersensitivity to sheep red blood cells (SRBC) in mice. Among spergualin, 15-deoxyspergualin, and N-30, 15-deoxyspergualin was most effective in suppressing immune responses. It suppressed antibody formation against SRBC by spleen cell cultures in a dose-dependent fashion without reducing cell viability. The spergualins also suppressed the mixed lymphocyte culture reaction. Peritoneal exudate cells taken from mice given immunosuppressive doses of 15-deoxyspergualin were not reduced in their functions measured: Release of lysosomal enzymes and production of superoxide anions. 15-Deoxyspergualin and N-30 were markedly effective in prolonging skin graft in rats.
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
February 1991,
Transplantation proceedings,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
January 1991,
Drugs under experimental and clinical research,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
February 1991,
Transplantation proceedings,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
February 1989,
Transplantation proceedings,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
February 1989,
Transplantation proceedings,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
April 1987,
The Journal of antibiotics,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
September 1996,
European journal of pharmacology,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
February 1988,
Transplantation proceedings,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
August 1992,
Nihon Geka Gakkai zasshi,
T Masuda, and
S Mizutani, and
M Iijima, and
H Odai, and
H Suda, and
M Ishizuka, and
T Takeuchi, and
H Umezawa
April 1994,
Transplantation proceedings,
