Biomaterial Database

Chick embryo area vasculosa as an in vivo assay for the screening of angiogenic and anti-angiogenic molecules. 2023

Domenico Ribatti, and Vincenzo Benagiano

Department of Translational Biomedicine and Neurosciences, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, 70124 Bari, Italy. Electronic address: domenico.ribatti@uiba.it.

The chick embryo area vasculosa is an extraembryonic membrane that is commonly used in vivo to study both angiogenesis and anti-angiogenesis. This review article analyzes the possibility to use the area vasculosa as an in vivo assay for the screening of putative angiogenic and anti-angiogenic molecules in alternative to the chorioallantoic membrane, more useful to study tumor growth, angiogenesis, and metastasis, and the angiogenic activity of acellular scaffolds and organoids.

UI	MeSH Term	Description	Entries
D009369	Neoplasms	New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D002642	Chick Embryo	The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.	Embryo, Chick,Chick Embryos,Embryos, Chick
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D049033	Chorioallantoic Membrane	A highly vascularized extra-embryonic membrane, formed by the fusion of the CHORION and the ALLANTOIS. It is mostly found in BIRDS and REPTILES. It serves as a model for studying tumor or cell biology, such as angiogenesis and TISSUE TRANSPLANTATION.	Chorioallantoic Membranes,Membrane, Chorioallantoic,Membranes, Chorioallantoic
D018919	Neovascularization, Physiologic	The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.	Angiogenesis, Physiologic,Angiogenesis, Physiological,Neovascularization, Physiological,Physiologic Angiogenesis,Physiologic Neovascularization,Physiological Angiogenesis,Physiological Neovascularization