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The morpho-functional development of the visual area of the cerebral cortex of newborn rats and effects of serotonin (5-HT) on these processes were studied in long-term (up to 40 days) organotypic cultures. It was shown that systematic addition of 5-HT in physiological concentrations to the nutrient medium during cultivation of the explants stimulates glia proliferation, neuron differentiation, neuropil formation, axon myelination and synaptogenesis. Electrophysiological studies of cortical cells in 5-HT-treated cultures showed earlier exhibition of spontaneous activity, increased number (by 33%) of spontaneously firing neurons and prevalence of periodic (bursting) type of discharges. Cultivation of neurons in a medium with 5-HT approximates their sensitivity to 5-HT to that observed in situ. The data obtained are indicative of the stimulating effects of 5-HT on the morpho-functional development of the rat cerebral cortex in tissue culture.
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A R Chubakov, and
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A R Chubakov, and
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A R Chubakov, and
E A Gromova, and
G V Konovalov, and
E F Sarkisova, and
E I Chumasov
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Brain research,
A R Chubakov, and
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G V Konovalov, and
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E I Chumasov
January 2010,
Morfologiia (Saint Petersburg, Russia),
A R Chubakov, and
E A Gromova, and
G V Konovalov, and
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E I Chumasov
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