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Twenty eight Italian patients with primary Sjögren's syndrome were typed for class I and class II alloantigens of the major histocompatibility complex. Patients with Sjögren's syndrome had higher prevalence of DR3 (46.4% v 14% in the control population, p corrected less than 0.02), while similar prevalence was found for DR2 and DRw52 alloantigens. DR3 correlated with DRw52 (p less than 0.0001), anti-Ro(SSA) (p less than 0.0002) and anti-La(SSB) (p less than 0.02) antibodies, and extraglandular manifestations (p less than 0.02). In addition, extraglandular involvement was associated with anti-Ro antibodies (p less than 0.05) and raised gammaglobulins (p less than 0.02). In Italian patients with primary Sjögren's syndrome DR3 is the genetic marker related to this clinical entity and seems to identify a disease subset characterised by autoantibody production and extraglandular manifestations.
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
January 1988,
Terapevticheskii arkhiv,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
January 2002,
Joint bone spine,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
June 2002,
Seminars in arthritis and rheumatism,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
January 1990,
Haematologia,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
January 2006,
Scandinavian journal of rheumatology,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
February 1991,
Italian journal of neurological sciences,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
December 1997,
The Journal of rheumatology,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
August 1992,
The Journal of rheumatology,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
January 1994,
Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna,
C Vitali, and
A Tavoni, and
G Rizzo, and
R Neri, and
A D'Ascanio, and
R Cristofani, and
S Bombardieri
January 2002,
Bratislavske lekarske listy,
