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After inhalation of increased concentrations of histamine solutions, equids had a decrease in dynamic compliance (Cdyn) and an increase in airway resistance, work of breathing, and maximum intrathoracic differences in pressure. Because the change in Cdyn correlated best with the inhaled histamine concentrations, airway reactivity was assessed by the decrease in Cdyn. With the use of linear regression, histamine concentrations were calculated; this resulted in a 35% reduction of Cdyn and these concentrations were defined as 35% provoking concentration Cdyn. The histamine inhalation provocation test was carried out in 40 equids. Nonspecific airway hyperreactivity was not present in equids that did not have clinical signs of respiratory tract disease, but it was present in 25% of the equids with low-grade lung disease and in all equids with severe lung disease.
H J Klein, and
E Deegen
December 1986,
Arhiv za higijenu rada i toksikologiju,
H J Klein, and
E Deegen
January 1984,
Respiration; international review of thoracic diseases,
H J Klein, and
E Deegen
August 1987,
Casopis lekaru ceskych,
H J Klein, and
E Deegen
August 1991,
Pneumologie (Stuttgart, Germany),
H J Klein, and
E Deegen
February 1990,
Pneumologie (Stuttgart, Germany),
H J Klein, and
E Deegen
January 1997,
Pneumonologia i alergologia polska,
H J Klein, and
E Deegen
April 1994,
Annals of allergy,
H J Klein, and
E Deegen
January 1994,
Pneumoftiziologia : revista Societatii Romane de Pneumoftiziologie,
H J Klein, and
E Deegen
August 1991,
Pneumologie (Stuttgart, Germany),
H J Klein, and
E Deegen
September 1981,
The New England journal of medicine,
