-transparent.png){kind=logo}
By chromosome walking in the major histocompatibility complex (MHC) of the BALB/c mouse, we have linked the K region to the I region at the molecular level. Forty-nine overlapping cosmid clones define a stretch of about 600 kb of DNA containing 2 class I and 7 class II genes. Eleven independent recombination events were mapped between the K and the I region marker loci by Southern blot analysis of polymorphic restriction sites. Eight of these events involved crossing-over, at an unusually high frequency of 0.6%-1.5% between genes from Mus musculus castaneus and laboratory mouse strains, and they were confined to two small stretches of DNA. We conclude that recombination hotspots are present at these positions in the two M.m. castaneus MHC haplotypes tested. In contrast, several MHC haplotypes of laboratory mice appear to lack those hotspots.
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
January 1994,
Immunogenetics,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
January 1986,
Lijecnicki vjesnik,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
January 1993,
Genetica,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
January 1984,
Cell,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
January 1990,
Immunogenetics,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
May 1999,
Immunogenetics,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
March 1985,
Proceedings of the National Academy of Sciences of the United States of America,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
February 1989,
The Journal of experimental medicine,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
May 1985,
Proceedings of the National Academy of Sciences of the United States of America,
M Steinmetz, and
D Stephan, and
K Fischer Lindahl
May 1997,
Proceedings of the National Academy of Sciences of the United States of America,
