Biomaterial Database

Effects of the beta-carboline FG 7142 on saccharin preference and quinine aversion in water-deprived rats. 1986

S J Cooper

Three groups of water-deprived male rats were given the choice of 0.05% sodium saccharin solution and water; 0.0005% quinine solution and water; water in both containers. N'-Methyl-beta-carboline-3-carboxamide (FG 7142), a benzodiazepine receptor inverse agonist, dose-dependently (2.5-10 mg X kg-1 i.p.) reduced intake of fluid in each group. The saccharin-choice group were most sensitive, showing a significant reduction at 2.5 mg X kg-1. Preference for the saccharin solution was reduced by FG 7142 but it did not increase aversion to the quinine solution. Hence, FG 7142 did not generally increase the rejection of flavoured solutions in a two-bottle test. A previously proposed "proconflict" effect of FG 7142 is discussed, in the light of these results.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011803	Quinine	An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.	Biquinate,Legatrim,Myoquin,Quinamm,Quinbisan,Quinbisul,Quindan,Quinimax,Quinine Bisulfate,Quinine Hydrochloride,Quinine Lafran,Quinine Sulfate,Quinine Sulphate,Quinine-Odan,Quinoctal,Quinson,Quinsul,Strema,Surquina,Bisulfate, Quinine,Hydrochloride, Quinine,Sulfate, Quinine,Sulphate, Quinine
D002243	Carbolines	A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.	Carboline,Pyrido(4,3-b)Indole,Beta-Carbolines,Pyrido(4,3-b)Indoles,Beta Carbolines
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004327	Drinking Behavior	Behaviors associated with the ingesting of water and other liquids; includes rhythmic patterns of drinking (time intervals - onset and duration), frequency and satiety.	Behavior, Drinking,Behaviors, Drinking,Drinking Behaviors
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012439	Saccharin	Flavoring agent and non-nutritive sweetener.	Saccharin Calcium,Saccharin Sodium,Calcium, Saccharin
D014868	Water Deprivation	The withholding of water in a structured experimental situation.	Deprivation, Water,Deprivations, Water,Water Deprivations
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus