-transparent.png){kind=logo}
Glia maturation factor (GMF), a 14,000 Mr acidic protein of the brain, is capable of promoting differentiation of cultured astroblasts. In this study we report the effect of GMF on two glioma cell lines: the C6 line, of rodent origin, and the HG-1 line, of human origin. When tested in culture, GMF promotes the initial growth of the two cell lines when the cells are sparse but limits proliferation by restoring contact inhibition when the cells are confluent. Cell cycle analysis confirms the arrest of the cells at the G0/G1 phase when the tumor cells are contact inhibited by GMF. When C6 cells are inoculated into the athymic (nude) mice at a s.c. site, a single solid tumor grows out with a 100% take. Intraperitoneal injection of GMF leads to the slowing down of tumor growth. That the in vivo effect of GMF is not due to cytotoxicity is evidenced by the lack of necrosis and by the appearance of more mature astrocytic cells in the tumors. The results lend support to the concept of GMF as a cellular regulator and suggest the therapeutic potential of GMF for brain tumors.
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
January 1989,
Anticancer research,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
August 1987,
Cancer research,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
December 1984,
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
February 2011,
Brain research,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
January 1980,
Current topics in developmental biology,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
September 2002,
Journal of neuro-oncology,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
May 1989,
Proceedings of the National Academy of Sciences of the United States of America,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
June 1981,
Brain research,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
November 1982,
Brain research,
R Lim, and
D J Hicklin, and
T C Ryken, and
X M Han, and
K N Liu, and
J F Miller, and
B A Baggenstoss
February 2000,
Journal of neurochemistry,
