-transparent.png){kind=logo}
Based on our recent findings that danazol, an isoxazol derivative of ethinyltestosterone, has a profound growth-inhibitory effect on an established human endometrial adenocarcinoma cell line, the effects of danazol on cancer cells from human endometrial adenocarcinomas obtained by hysterectomy were investigated in the present study. Of the 22 uterine adenocarcinomas, estrogen, progesterone, and androgen receptors were found in 12, 14, and 4 tumors, respectively. Competitive binding studies showed that danazol specifically binds to progesterone and androgen receptors but not to estrogen receptors. Of the five cancer cells from five patients succeeded in primary cell culture, a marked inhibition of cell growth was demonstrated by addition of danazol in two cancer cells having progesterone but not androgen receptors. However, danazol did not affect the growth of the remaining three cancer cells lacking progesterone receptors. These results strongly suggest that danazol has a significant growth-inhibitory effect on human endometrial adenocarcinoma cells, possibly through progesterone receptors in the cells.
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
April 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
June 1994,
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
January 1999,
Clinical and experimental obstetrics & gynecology,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
February 1988,
Fertility and sterility,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
February 2002,
Cancer research,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
August 1988,
Journal of steroid biochemistry,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
January 1994,
Zhonghua bing li xue za zhi = Chinese journal of pathology,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
December 2012,
Panminerva medica,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
November 1996,
The Journal of clinical endocrinology and metabolism,
H Ikegami, and
N Terakawa, and
I Shimizu, and
H Kano, and
Y Tanaka, and
T Aono, and
O Tanizawa, and
K Matsumoto
May 2002,
Fertility and sterility,
