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Diabetes mellitus, steatorrhea, cholelithiasis and a tumor distorting the duodenum prompted a work-up for somatostatinoma in a 52-year-old man. The responses of pancreatic B-cells but not of A-cells to nutrient stimuli were inhibited, and growth-hormone release was suppressed, suggesting somatostatin resistance in some target tissues. Plasma somatostatin-like immunoreactivity ranged from 9000 to 13,000 pg per milliliter (normal: 88+/-8, mean +/- S.E.M.) and was distributed in four molecular forms, including free somatostatin. The primary tumor contained 5 microgram of somatostatin-like immunoreactivity per milligram of wet tissue, distributed in three of the molecular forms noted in plasma. Plasma calcitonin was also elevated (4650 pg per milliliter; normal: less than 120). Immunocytochemical studies showed that cells of the primary tumor contained somatostatin and calcitonin but no other peptide hormones. Only somatostatin was present in the metastases. Somatostatin was localized electron microscopically in all secretory granules, irrespective of size and shape, whereas calcitonin was present only within a single subpopulation of small granules in the same cells.
G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
July 1983,
Klinische Wochenschrift,
G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
January 1975,
Neurology,
G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
March 1977,
Lancet (London, England),
G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
May 1981,
The Journal of clinical endocrinology and metabolism,
G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
November 1979,
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G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
July 1972,
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G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
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D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
January 1991,
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G J Krejs, and
L Orci, and
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M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
December 1959,
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G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
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P Raskin, and
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D Baetens, and
A Rubenstein, and
T A Aldor, and
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October 1993,
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G J Krejs, and
L Orci, and
J M Conlon, and
M Ravazzola, and
G R Davis, and
P Raskin, and
S M Collins, and
D M McCarthy, and
D Baetens, and
A Rubenstein, and
T A Aldor, and
R H Unger
March 1982,
Medicina clinica,
