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A case of somatostatinoma syndrome in a 30-year-old woman is presented. Basal levels of growth hormone and of pancreatic and gastric hormones were reduced and the response of growth hormone, insulin and C-peptide to stimuli such as arginine, glucose, glibenclamide and calcium was virtually abolished. Similarly, gastric acid secretion, pancreatic exocrine function and intestinal absorption were significantly reduced. On the other hand, basal and stimulated levels of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH) were within the normal range. Plasma somatostatin-like immunoreactivity was increased to 600-2,000 pg/ml (normal: 88-140 pg/ml). Immunocytochemical studies demonstrated the presence of somatostatin immunoreactive material in the primary tumour in the head of the pancreas and in the liver metastases. In spite of two courses of chemotherapy with streptozotocin and 5-fluorouracil the patient died due to liver failure 5 months after the first admission to hospital.
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
May 1981,
The Journal of clinical endocrinology and metabolism,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
August 1979,
The New England journal of medicine,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
March 1977,
Lancet (London, England),
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
November 1979,
AJR. American journal of roentgenology,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
January 2007,
Current pharmaceutical design,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
December 1958,
Minerva otorinolaringologica,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
April 1994,
Lupus,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
December 1979,
Minerva ginecologica,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
January 1973,
Ftiziologia,
V Schusdziarra, and
D Grube, and
H Seifert, and
J Galle, and
H Etzrodt, and
W Beischer, and
O Haferkamp, and
E F Pfeiffer
January 1990,
Acta gastro-enterologica Belgica,
