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NH4OAc/DMSO-Promoted Benzylation of Pyrrolo[2,1-a]isoquinolines. 2023

Xiao-Hui Chen, and Tsesong Lhazom, and Hai-Lei Cui
Laboratory of Asymmetric Synthesis, College of Chemistry and Environmental Engineering, Chongqing University of Arts and Sciences, 319 Honghe Avenue, Yongchuan, Chongqing 402160, P. R. China.

Benzylation of pyrrolo[2,1-a]isoquinoline derivatives has been realized with various phenols by the use of ammonium acetate as a promoter (20 examples, up to 84% yield). DMSO served as the source of methylene and solvent. The employment of iron chloride as a catalyst can also afford the desired benzylated products in moderate to good yields (11 examples, up to a 74% yield).

UI MeSH Term Description Entries

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