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The time dependence of the distribution of intravenously injected radiolabelled Candida albicans in the body of mice was studied. The Candida cells were labelled by cultivating them 7 days at 28 degrees C in a medium containing one of the following radionuclides: 46Sc, 95Nb, 59Fe, 144ce, 89Sr, 60Co, 65Zn, 54Mn, 45Ca, 51Cr and 91Y, which are listed in decreasing order in respect to amount bound. The labelled cells were killed by heating them 120 min at 60 degrees C, without loss of immunologic properties. Owing to the amount and strength of binding, 144Ce labelled Candida, together with 14C labelled cells was used in animal kinetic study. A rapid disappearance of the labelled cells from blood, interrupted by a small peak, was paralleled by a transient uptake in lungs and followed by a long lasting accumulation in the liver. The kidneys and spleen revealed only small uptakes of the labelled material.
T Trnovec, and
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A Gajdosík, and
V Koprda
April 1993,
The Journal of infectious diseases,
T Trnovec, and
D Sikl, and
M Zemánek, and
V Faberová, and
S Bezek, and
A Gajdosík, and
V Koprda
April 1975,
The Journal of pharmacy and pharmacology,
T Trnovec, and
D Sikl, and
M Zemánek, and
V Faberová, and
S Bezek, and
A Gajdosík, and
V Koprda
January 1979,
Polski przeglad radiologii i medycyny nuklearnej,
T Trnovec, and
D Sikl, and
M Zemánek, and
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S Bezek, and
A Gajdosík, and
V Koprda
January 1974,
Physiologia Bohemoslovaca,
T Trnovec, and
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M Zemánek, and
V Faberová, and
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A Gajdosík, and
V Koprda
June 1992,
Journal of anatomy,
T Trnovec, and
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S Bezek, and
A Gajdosík, and
V Koprda
May 1991,
Biochemical pharmacology,
T Trnovec, and
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A Gajdosík, and
V Koprda
June 1989,
Journal of pharmaceutical sciences,
T Trnovec, and
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V Koprda
February 2003,
Critical care medicine,
T Trnovec, and
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V Faberová, and
S Bezek, and
A Gajdosík, and
V Koprda
November 2000,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
T Trnovec, and
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A Gajdosík, and
V Koprda
July 1964,
Archives internationales de pharmacodynamie et de therapie,
