BIOMAT Database Logo BIOMAT Database Logo

Relationship of train-of-four ratio to twitch depression during pancuronium-induced neuromuscular blockade. 1986

G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey

The relationship of train-of-four (TOF) ratio to the depression of the first twitch (TD) was investigated in 16 patients given pancuronium in doses insufficient to eliminate the fourth response in the train. In ten patients the block was allowed to spontaneously recover (Group 1) and in six it was reversed with neostigmine (Group 2) once maximum depression of TOF ratio had occurred. Maximum depression of the first response occurred in 6.5 +/- 4.3 min (mean +/- SD). Maximum depression of the TOF ratio was not present until 28.0 +/- 11.0 min. TOF ratio was usually still decreasing when recovery of TD had begun. However, once the TOF ratio began to recover, the recovery rates for TD and TOF ratio were similar in both the spontaneously recovering and the reversed groups. TOF ratio at complete TD recovery was 74.9 +/- 15.7 and 86.2 +/- 15.4% for the two groups. A kinetic analysis yielded significantly different elimination rate constants for the two effects from the "effect compartment." These findings suggest that these two effects of pancuronium are exerted at different sites.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D009469 Neuromuscular Junction The synapse between a neuron and a muscle. Myoneural Junction,Nerve-Muscle Preparation,Junction, Myoneural,Junction, Neuromuscular,Junctions, Myoneural,Junctions, Neuromuscular,Myoneural Junctions,Nerve Muscle Preparation,Nerve-Muscle Preparations,Neuromuscular Junctions,Preparation, Nerve-Muscle,Preparations, Nerve-Muscle
D010197 Pancuronium A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than CURARE but has less effect on the circulatory system and on histamine release. Pancuronium Bromide,Pancuronium Curamed,Pancuronium Organon,Pavulon,Bromide, Pancuronium
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014403 Tubocurarine A neuromuscular blocker and active ingredient in CURARE; plant based alkaloid of Menispermaceae. Tubocurare,Tubocurarine Chloride,d-Tubocurare,d-Tubocurarine

Related Publications

G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Relationship between first-twitch depression and train-of-four ratio during sugammadex reversal of rocuronium-induced neuromuscular blockade.
June 2016, Korean journal of anesthesiology,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Relationship between train-of-four ratio and first-twitch depression during neuromuscular blockade: a pharmacokinetic/dynamic explanation.
August 1990, Journal of pharmacokinetics and biopharmaceutics,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Twitch depression and train-of-four ratio after antagonism of pancuronium with edrophonium, neostigmine, or pyridostigmine.
March 1983, Anesthesia and analgesia,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
A close relationship between post-tetanic twitch and train-of-four responses during neuromuscular blockade by vecuronium.
April 1991, Journal of anesthesia,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Relationship between single twitch depression and train-of-four fade: influence of relaxant dose during onset and spontaneous offset of neuromuscular blockade.
July 1987, Anesthesia and analgesia,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Twitch tension and train-of-four ratio during prolonged neuromuscular monitoring at different peripheral temperatures.
April 1991, Acta anaesthesiologica Scandinavica,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Train-of-four to monitor neuromuscular blockade?
October 2004, Chest,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Twitch, tetanus and train-of-four as indices of recovery from nondepolarizing neuromuscular blockade.
April 1981, Anesthesiology,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Pancuronium-induced prolonged neuromuscular blockade.
December 1991, Critical care medicine,
G G Graham, and R Morris, and D A Pybus, and T A Torda, and R Woodey
Assessment of neuromuscular blockade using tetanic, single-twitch and train-of-four responses: discussion paper.
May 1984, Journal of the Royal Society of Medicine,
Copied contents to your clipboard!