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Infusion of nonradiolabelled dehydroepiandrosterone sulphate (DHA-S) has been used to investigate the possible formation of oestrone sulphate via a sulphated conjugate of androstenedione. The metabolic clearance rate (MCR) of DHA-S also was measured and the mean value (25 1/24h) was similar to values reported using isotopic techniques. Although conversion of DHA-S to 5-androstenediol, a steroid with oestrogenic properties, was detected during infusion of DHA-S, there were no significant increases in plasma levels of conjugated androstenedione or oestrone sulphate. The MCR's oestrone sulphate measured using infusion of nonradiolabelled steroid in two menopausal women were 99 1/24h and 121 1/24h. For one woman, the production rate of oestrone sulphate, calculated from the conversion of oestrone and oestradiol to oestrone sulphate (151 nmol/day) was similar to the measured production rate of oestrone sulphate (144 nmol/day). It is concluded that in menopausal women, oestrone sulphate is derived from conversion of oestrone and oestradiol with no formation occurring via conjugated androstenedione.
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
November 1992,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
November 1988,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
June 1987,
British journal of obstetrics and gynaecology,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
November 1980,
Clinical endocrinology,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
March 2000,
BJOG : an international journal of obstetrics and gynaecology,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
May 2007,
The Journal of steroid biochemistry and molecular biology,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
April 1984,
Maturitas,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
September 1977,
The Biochemical journal,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
July 1994,
The Journal of steroid biochemistry and molecular biology,
M J Reed, and
C T Noel, and
D L Jones, and
H S Jacobs, and
M J Scanlon, and
V H James
September 1982,
The Veterinary record,
